Lab Members

Research Focus

• We use mouse models to research molecular mechanisms underlying memory processing and formation.

• We use cytogenetic, molecular biological and genomic approaches to research patients with inherited or spontaneous brain disorders and screen for genes associated with these diseases. 

Education of PI

Education

1998-2003

Ph.D. 

University of Southern California, California, USA.

Thesis: The Role of Brain-derived Neurotrophic Factor (BDNF) in Fear Conditioning

Advisor: Dr. Richard F Thompson

1990-1992

M.Sc.

Indiana University, Bloomington, USA.

Thesis: The Interaction of Avirulence-Resistance Gene Pairs in Pseudomonas Syringae and Arabidopsis Thaliania

Advisor: Dr. Roger W Innes

1986-1990

B.Sc.

National Taiwan University, Taipei, Taiwan.

Professional Experience of PI

Current Positions 

Professor,   Institute of Medical Sciences, Tzu Chi University (Since 2014/08~)
Provost, Tzu Chi University (Since 2014/09~)
Director, Center for Faculty Development and Teaching Resources (Since 2013/08~)

Professional Experiences
1. Professor (2013/02-2014/07) Department of Molecular Biology and Human Genetics, Tzu Chi University

2. Associate Professor (Jul-2008 till Jan 2013) Department of Molecular Biology and Human Genetics, Tzu Chi University

3. Associate Professor/Chair (Aug-2003 till Jul-2008) Graduate Institute of Human Genetics, Tzu Chi University

4. Assistant Instructor (Sep-2001 till Jan-2002) Program for Neuroscience, University of Southern California Lecturer (Mar-1993 till Jul-2003, 1998-2003 took a leave of absence for Ph.D. training)

5. Lecturer, Institute of Cell Biology, Tzu Chi College(Mar-1993 till Jul-2003, 1998-2003 took a leave of absence for Ph.D. training)

6. Supervisor, Cytogenetic lab, Tzu Chi General Hospital (Mar-1993 till Jul-1998)

7. Teaching assistant (Sep-1990 till Aug-1991) Department of Biology, Indiana University, Bloomington

Publication

Journal Articles

1.        Ni-Chun Chung, Ying-Hsueh Huang, Chuan-Hsiung Chang, James C Liao, Chih-Hsien Yang, Chien-Chang Chen, Ingrid Y Liu (2015, Feb). Behavior training reverses asymmetry in hippocampal transcriptome of the Cav3.2 knockout mice . Plos One, 10(3): e0118832. 本人為通訊作者.

2.        Kuei-Fang Lee, Julia Tzu-Ya Weng, Paul Wei-Che Hsu, Yu-Hsiang Chi, Ching-Kai Chen, Ingrid Y Liu, Yi-Cheng Chen, Lawrence Shih-Hsin Wu (2014, Sep). Gene Expression profiling of biological pathway alterations by radiation exposure. BioMed Research International , Article ID 834087. (SCI).

3.        KF Lee, YC Chen, PWC Hsu, IY Liu, LSH Wu (2014). MicroRNA expression profiling altered by variant dosage of radiation exposure. BioMed Research International. (SCI).

4.        Chooi-Lan Lieu, Jui-Hung Yen, An-Bang Liu, Ingrid Y LIu* (2013, Dec). Sex differences in the effective warfarin dosage in Han and aboriginal Taiwanese patients with the VKORC1-1639AA genotype. Tzu Chi Medical Journal 25(4): 213-217. 本人為通訊作者.

5.        Ruo-Yu Wang, Rui-Zhe Phang, Pei-Hsuan Hsu, Wei-Hua Wang, Hsien-Ting Huang, Ingrid Y Liu* (2013, Mar). In vivo knockdown of hippocampal miR-132 expression impairs memory acquisition of trace fear conditioning. Hippocampus. (SCI, 36/251, Neuroscience). NSC 98-2314-B-320-001-MY3. 本人為通訊作者.

6.        Lee KF, Hsu CS, Kuo PL, Chen JL, Jiang YH, Liu IY* (2012, Sep). The identification of a spontaneous 47,XX,+21/46,XY chimeric fetus with male genitali. BMC Medical Genetics, 13:85. (SCI). 本人為通訊作者.

7.        Chien-Chang Chen, Jhe-Wei Shen, Ni-Chun Chung, Ming-Yuan Min, Shin-Jong Cheng, Ingrid Y Liu＊ (2012, Jan). Retrieval of context-associated memory is dependent on the Cav3.2 T-type calcium channel. PloS One, 7(1): e29384.. (SCI, 12/85, Biology). NSC 96-2314-B-320-003-MY3. 本人為通訊作者.

8.        Li-Ping Tsai†, Kuei-Fang Lee, Jye-Siung Fang, Ingrid Y Liu* (2011, Apr). Molecular cytogenetic analysis and clinical manifestations of a case with de novo mosaic ring chromosome 7. Molecular Cytogenetics, p4-5. (SCI). 本人為通訊作者.

9.        Wen-Kwei Chen, Ingrid Y Liu, Ya-Ting Chang, Yong-Cyuan Chen, Chih-Cheng Chen, Chen-Tung Yen,Hee-Sup Shin,Chien-Chang Chen* (2010, Aug). Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. The Journal of Neuroscience, 30(31),p.10360-p.10368. (SCI, 19/244, Neurosciences). NSC 96-2314-B-320-003-MY2.

10.     CHIA-WEI LIN, MING-JIUAN WU, INGRID Y.-C. LIU, JENG-DIAN SU,JUI-HUNG YEN* (2010, Apr). Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression. Agricutural and Food Chemistry, 58,p.4477-p.4486. (SCI, 3/57, Agricultural Multidisplines). NSC 97-2320-B-320-011-MY3.

11.     Ching-Hsun Huang, Yu-Wei Chiang, Keng-Chen Liang,Richard F. Thompson, Ingrid Y. Liu* (2010, Apr). Extra-cellular signal-regulated kinase 1/2 (ERK1/2) activated in the hippocampal CA1 neurons is critical for retrieval of auditory trace fear memory. Brain Research, 1326,p.143-p.151. (SCI, 126/244, Neurosciences). NSC 94-2314-B-320-011-MY3. 本人為通訊作者.

12.     Ingrid Y.C. Liu, W. Ernest Lyons, Laura A. Mamounas, and Richard F. Thompson* (2004, Sep). Brain-Derived Neurotrophic Factor Plays a Critical Role in Contextual Fear Conditioning. The Journal of Neuroscience, 24(36):7958-7963. (SCI). 本人為第一作者.

13.     Ruolan Liu, Ingrid Y. Liu, Michel Baudry* et. al. (2003, Jul). Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase catalase mimetics. Proceedings of the National Academy of Sciences, 100期, P.8526-P.8531. (SCI).

Thesis

1.        Ingrid Y Liu. THE ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) IN FEAR CONDITIONING. The role of brain-derived neurotrophic factor (BDNF) in fear conditioning. University of Southern California. Aug, 2003: P.1-P.96.

Teachings

1. Seminar in Human Genetics (Coordinator; required course for M.S. program)
2. Human Genetics (Coordinator; required course for M.S. program, Teaching the part of Neuronal signaling)
3. Behavioral Genetics (Independent instructor; course for M.S. program, Teaching in English)
4. Neuroscience (Teaching the chapter of Cognitive Neuroscience; course for M.S. program )
5. Molecular Biology of Learning and Memory (Independent instructor; course for M.S. program)
6. Developmental Biology (Teaching the part “Development of Nervous System”; course for M.S. program)
7. Animal Models (Teaching the part “Animal models for studying disorders of learning and memory”; course for M.S. program)
8. Biology (Teaching the part of “Introduction of Neuroscience”; required course for undergraduate program)
9. Exercise for Biology (Independent instructor; required course for undergraduate program)

Professional Services

• Scientific programs production, Daai TV Station, funded by National Science Council, 2007-2010 
• Reviewer-Brain Research, J of European Neuropsychology, Plos One, Tzu Chi Medical Journal 
• Member of Society for Neuroscience 
• Member of European Society for Neuroscience 
• Member of Taiwan Society for Human Genetics 
• Member of Taiwan Society for Fundamental Neuroscience 
• Organizer-Annual Conference for Society of Human Genetics, Taiwan, 2006; Annual Conference for Taiwan Society of Fundamental Neuroscience, 2014